A Prospective Randomised Study Of Camparison Of Intrathecal Ropivacaine (0.75%) 15mg With Fentanyl (25mcg) And Bupivacaine (0.5%) 10mg With Fentanyl (25mcg) For Spinal Anaesthesia For Lower Limb Surgeries

Background: The propyl derivative of the pipecoloxylidides was less toxic than the butyl derivative (bupivacaine). Further work revealed that the nerve blocking properties of the R and S enantiomers were similar but that the S-enantiomer was less cardiotoxic. Thus the S enantiomer of the propyl derivative (Ropivacaine) was chosen for further development.Ropivacaine,structurally resembling bupivacaine, with a propyl group on the piperidine nitrogen atom of the molecule is a relatively new amino-amide anaesthetic agent, similar in chemical structure to bupivacaine has been recently launched in India, for clinical evaluation having various advantages like early onset and shorter duration of action and having lesser cardio toxicity as compared to bupivacaine. The drug ropivacaine, relieves the psychological distress of being immobile for a longer period of time after lower abdominal surgeries.In view of the above context the present study was undertaken for comparison of isobaric ropivacaine and isobaric bupivacaine to determine clinical efficacy of ropivacaine. Materials and Methods: We conducted this study as a prospective randomized study. A total of 100 adult patients were randomly selected who fulfilled the inclusion criteria. They were divided into groups and study was conducted. Results: In this study,we measured the results of each drug by its action on onset and peak of sensory and motor blockade. Conclusion: From our study we conclude that both Bupivacaine and Ropivacaine with 25 mcgms of fentanyl intrathecally, promote satisfactory anaesthesia for lower limb surgeries. The spinal anaesthesia with intrathecal Ropivacaine 15 mg provides a faster motor recovery as compared with Bupivacaine 10 mg which is more suitable for ambulatory lower extremity surgeries of approximately two hours.